PRP for Jumpers Knee: A Comprehensive Guide

Introduction: What is Patellar Tendinopathy, Jumper’s Knee?

PRP for Jumpers Knee
PRP for Jumper’s Knee can be a very effective treatment

Jumper’s knee, also known as patellar tendinopathy, is a chronic overuse injury affecting the patellar tendon, which joins the the knee cap (patella) to the shin bone (tibia). This condition is prevalent among athletes involved in sports that require repetitive jumping and explosive movements, such as volleyball and basketball.​1–3​ This comprehensive review focuses on the efficacy and safety of platelet-rich plasma, PRP for Jumpers Knee.

What causes Patellar Tendinopathy, Jumper’s Knee?

The etiology of jumper’s knee involves repetitive microtrauma and overload of the extensor mechanism of the knee, leading to degenerative changes rather than inflammatory processes. Histopathological findings include collagen disorganization, mucoid degeneration, and neovascularization. Risk factors include intrinsic factors such as ligamentous laxity, increased Q-angle, and patella alta, as well as extrinsic factors like training frequency, surface hardness, and level of performance.​1,4​

How is Jumper’s Knee diagnosed?

Clinically, jumper’s knee presents with anterior knee pain localized to the patellar tendon, which is exacerbated by activities involving knee extension, such as jumping or squatting. Diagnosis is primarily clinical, supported by imaging modalities like ultrasound and MRI to assess tendon structure and rule out differential diagnoses.​1,2​

What are typical treatment options for Jumper’s Knee?

Management for Jumper’s Knee may include:

  • Conservative measures, including activity modification, eccentric strengthening exercises,
  • Cryotherapy,
  • Nonsteroidal anti-inflammatory drugs (NSAIDs).

What are some advanced treatments for Jumper’s Knee?

  • Extracorporeal shockwave therapy (ESWT),
  • Platelet-rich plasma injections, PRP for Jumpers Knee
  • Dry needling. ​2,3,5​
  • Surgical intervention is considered for recalcitrant cases and involves debridement of the degenerative tissue, with both open and arthroscopic techniques showing similar efficacy.​1,6,7​

Can PRP injections help with Patellar Tendinopathy, Jumper’s Knee?

Platelet-rich plasma therapy, PRP for jumpers knee, has emerged as a potential treatment for jumper’s knee. PRP is an autologous blood product enriched with platelets, which release growth factors that may enhance tendon healing. The preparation involves centrifugation of the patient’s blood to concentrate platelets, which are then injected into the affected tendon.​8​ PRP is also useful for other conditions of the knee, such as knee osteoarthritis.

PRP for Jumpers Knee

What does the research say about using PRP for Jumpers knee, patellar tendinopathy?

Clinical studies have shown generally promising results for PRP in treating chronic patellar tendinopathy:

  • A study by Kaux demonstrated that a single PRP injection combined with a submaximal eccentric rehabilitation protocol significantly reduced pain in patients with chronic jumper’s knee, although functional improvements were not statistically significant.​9​
  • Another study by Filardo et al. reported that multiple PRP injections led to significant improvements in pain and functional scores in patients with refractory patellar tendinopathy, with further benefits observed after the addition of physiotherapy.​10​
  • Charousset et al. conducted a prospective study on athletes with chronic patellar tendinopathy and found that three consecutive ultrasound-guided PRP injections significantly improved VISA-P, VAS, and Lysholm scores at a two-year follow-up. Additionally, MRI assessments showed improved tendon structural integrity in a majority of patients.​11​
  • A randomized controlled trial comparing PRP injections to extracorporeal shock-wave therapy (ESWT) found that PRP led to greater improvements in pain and functional scores at 6 and 12 months.​12​
  • A systematic review by Liddle and Rodríguez-Merchán concluded that PRP is a safe and promising therapy for recalcitrant patellar tendinopathy, although its superiority over other treatments such as physical therapy remains unproven.​13​

Risks and side effects of PRP for Jumpers Knee therapy 

The use of platelet-rich plasma (PRP) for patellar tendinopathy, or jumper’s knee, is generally considered safe, but it is not without risks and potential side effects. The most commonly reported adverse effects include:

1. Inflammatory Reactions: An local inflammatory response is expected after most PRP treatments.  This usually lasts for 3-5 days after a treatment, although it may be longer and more severe after tendon treatments with PRP.  This is usually managed with rest, ice, and sometimes prescription pain medications.  There are also case reports of more severe reaction, as documented in a case involving a type 1 diabetic patient. This reaction may manifest as increased pain, swelling, and redness at the injection site. ​14​

2. Symptom Exacerbation: There have been reports of worsening patellar tendinitis following PRP treatment. Patients may experience increased pain, tendon thickening, and even osteolysis of the distal pole of the patella.​15​

3. Tendon Rupture: Although rare, there is a documented case of patellar tendon rupture following a series of PRP injections. This case involved a 40-year-old male soccer player who experienced a complete tendon rupture with severe degenerative changes.​16​  Although, it should be remembered that this is a single case report, and the patient had returned to playing sports soon after the treatment with considerably lower amounts of painful symptoms as reported by the authors in a later update.  It should be noted that there is a much higher risk of tendon rupture with steroid (cortisone) injections near tendons. ​17–19​

4. General Adverse Events: While PRP is generally considered to have a favorable side effect profile, minor complications such as pain at the injection site, infection, and local tissue damage can occur. However, these are relatively uncommon and usually mild.​20​

PRP type and dose greatly influences success or failure of PRP treatment 

It is important to remember that not all PRP is the same, and the dose of platelets in one type of PRP preparation may be over 200x lower or higher than another type of PRP preparation.  Although this fact is seldom addressed at most PRP clinics, it is very important and the main reason why so many patients see no effect from their PRP treatments.

PRP Concentration, Dose and Composition are Keys to Success

The concentration and dose of platelets in the PRP preparation, as well as the specific technique used for injection, are crucial factors that can significantly impact the overall efficacy and outcomes of the treatment.

Additionally, the composition of PRP can vary, which may influence the risk of adverse effects. For instance, leukocyte-rich PRP (L-PRP) has been shown to induce more inflammatory and catabolic changes compared to pure PRP (P-PRP).​21​

PRP must be checked before use by hematology analysis to ensure that it meets the required standards for optimal therapeutic benefits and patient safety.

The only way to be sure of the concentration, dose, and composition of PRP is to analyze the PRP before use before each treatment.  This requires the use of a hematology analyzer which is unfortunately quite rare.  Without  hematology analysis of the PRP, there is no guarantee of the type of PRP treatment you are getting.

 Therefore, investing in a reliable hematology analyzer for PRP analysis is crucial for healthcare providers looking to deliver consistent and effective treatments to their patients.

Summary: PRP Therapy for Patellar Tedinopathy (Jumper’s Knee) can be effective, but only if the PRP is prepared properly and analyzed for quality and concentration before use.

In summary, while PRP therapy for patellar tendinopathy is generally safe, it carries risks such as inflammatory reactions, symptom exacerbation, and, in rare cases, tendon rupture. Careful patient selection and standardized PRP preparation protocols are essential to minimize these risks.

Who is the best Candidate for PRP for Patellar Tendinopathy?

The best candidate for PRP therapy for patellar tendinopathy is typically a patient who has not responded well to conservative treatments such as physical therapy, rest, and anti-inflammatory medications. Additionally, younger patients seem to respond better to PRP therapy compared to older individuals due to their potentially higher baseline regenerative capacity and healing potential. Furthermore, individuals with chronic patellar tendinopathy who have persistent pain and functional limitations despite conservative treatments may also benefit from PRP therapy as it can stimulate tissue repair and regeneration in the affected tendon.

Will PRP work for you?

To find out if PRP might be a viable option for you, we invite you to book a consultation with our doctor. During the consultation, our doctor will review your medical history, symptoms and treatment goals to help decide if PRP therapy is a suitable course of action for your individual needs. Additional lab tests or imaging studies may be ordered, including X-rays, ultrasound, or MRI to help assess your specific condition. Based on the results of these tests, our doctor will be able to provide you with a personalized treatment plan tailored to address your unique situation and optimize the potential benefits of PRP therapy.


  1. 1.
    Tibesku CO, Pässler HH. Jumper’s knee – eine Übersicht. Sportverletz Sportschaden. Published online June 2005:63-71. doi:10.1055/s-2005-858141
  2. 2.
    Walton J, Kozina E, Woo F, Jadidi S. A Review of Patellar Tendinopathy in Athletes Involved in Jumping Sports. Cureus. Published online October 22, 2023. doi:10.7759/cureus.47459
  3. 3.
    Theodorou A, Komnos G, Hantes M. Patellar tendinopathy: an overview of prevalence, risk factors, screening, diagnosis, treatment and prevention. Arch Orthop Trauma Surg. Published online August 4, 2023:6695-6705. doi:10.1007/s00402-023-04998-5
  4. 4.
    Aksu N, Atansay V, Karalök I, Aksu T, Kara AN, Hamzaoglu A. Relationship of Patellofemoral Angles and Tibiofemoral Rotational Angles With Jumper’s Knee in Professional Dancers: An MRI Analysis. Orthopaedic Journal of Sports Medicine. Published online March 1, 2021:232596712098522. doi:10.1177/2325967120985229
  5. 5.
    Sharif F, Ahmad A, Gilani SA, Bacha R, Hanif A, Arif MA. Efficacy of ultrasound guided dry needling as an adjunct to conventional physical therapy for patients with jumper’s knee: A randomized controlled trial. Front Surg. Published online November 4, 2022. doi:10.3389/fsurg.2022.1023902
  6. 6.
    Stuhlman CR, Stowers K, Stowers L, Smith J. Current Concepts and the Role of Surgery in the Treatment of Jumper’s Knee. Orthopedics. Published online November 2016. doi:10.3928/01477447-20160714-06
  7. 7.
    Arner JW, Kaeding CC, Bradley JP. Management of Patellar Tendinopathy. Arthroscopy: The Journal of Arthroscopic & Related Surgery. Published online January 2024:13-15. doi:10.1016/j.arthro.2023.09.004
  8. 8.
    Lopez-Vidriero E, Goulding KA, Simon DA, Sanchez M, Johnson DH. The Use of Platelet-Rich Plasma in Arthroscopy and Sports Medicine: Optimizing the Healing Environment. Arthroscopy: The Journal of Arthroscopic & Related Surgery. Published online February 2010:269-278. doi:10.1016/j.arthro.2009.11.015
  9. 9.
    Kaux J, Croisier J, Bruyere O, et al. One injection of platelet-rich plasma associated to a submaximal eccentric protocol to treat chronic jumper’s knee. J Sports Med Phys Fitness. 2015;55(9):953-961.
  10. 10.
    Filardo G, Kon E, Della Villa S, Vincentelli F, Fornasari PM, Marcacci M. Use of platelet-rich plasma for the treatment of refractory jumper’s knee. International Orthopaedics (SICOT). Published online July 31, 2009:909-915. doi:10.1007/s00264-009-0845-7
  11. 11.
    Charousset C, Zaoui A, Bellaiche L, Bouyer B. Are Multiple Platelet-Rich Plasma Injections Useful for Treatment of Chronic Patellar Tendinopathy in Athletes? Am J Sports Med. Published online February 11, 2014:906-911. doi:10.1177/0363546513519964
  12. 12.
    Smith J, Sellon JL. Comparing PRP Injections With ESWT for Athletes With Chronic Patellar Tendinopathy. Clinical Journal of Sport Medicine. Published online January 2014:88-89. doi:10.1097/jsm.0000000000000063
  13. 13.
    Liddle AD, Rodríguez-Merchán EC. Platelet-Rich Plasma in the Treatment of Patellar Tendinopathy. Am J Sports Med. Published online December 18, 2014:2583-2590. doi:10.1177/0363546514560726
  14. 14.
    Kaux JF, Croisier JL, Léonard P, Le Goff C, Crielaard JM. Exuberant Inflammatory Reaction as a Side Effect of Platelet-Rich Plasma Injection in Treating One Case of Tendinopathy. Clinical Journal of Sport Medicine. Published online March 2014:150-152. doi:10.1097/jsm.0b013e31829aa410
  15. 15.
    Bowman KF Jr, Muller B, Middleton K, Fink C, Harner CD, Fu FH. Progression of patellar tendinitis following treatment with platelet-rich plasma: case reports. Knee Surg Sports Traumatol Arthrosc. Published online June 1, 2013:2035-2039. doi:10.1007/s00167-013-2549-1
  16. 16.
    Redler A, Proietti L, Mazza D, et al. Rupture of the Patellar Tendon After Platelet-Rich Plasma Treatment: A Case Report. Clinical Journal of Sport Medicine. Published online January 2020:e20-e22. doi:10.1097/jsm.0000000000000703
  17. 17.
    Brand JC, Hardy R. Editorial Commentary: Platelet-Rich Plasma May Be Superior to Corticosteroid Injection for Rotator Cuff Disease Because of Improved Chance of Healing, Longer-Lasting Pain Relief, and No Detriment if Surgery Is Needed. Arthroscopy: The Journal of Arthroscopic & Related Surgery. Published online February 2023:422-424. doi:10.1016/j.arthro.2022.08.029
  18. 18.
    Tanpowpong T, Thepsoparn M, Numkarunarunrote N, Itthipanichpong T, Limskul D, Thanphraisan P. Effects of Platelet-Rich Plasma in Tear Size Reduction in Partial-Thickness Tear of the Supraspinatus Tendon Compared to Corticosteroids Injection. Sports Med – Open. Published online February 8, 2023. doi:10.1186/s40798-023-00556-w
  19. 19.
    Lin CY, Huang SC, Tzou SJ, et al. A Positive Correlation between Steroid Injections and Cuff Tendon Tears: A Cohort Study Using a Clinical Database. IJERPH. Published online April 8, 2022:4520. doi:10.3390/ijerph19084520
  20. 20.
    Mautner K, Kneer L. Treatment of Tendinopathies with Platelet-rich Plasma. Physical Medicine and Rehabilitation Clinics of North America. Published online November 2014:865-880. doi:10.1016/j.pmr.2014.06.008
  21. 21.
    Zhou Y, Zhang J, Wu H, Hogan MV, Wang JHC. The differential effects of leukocyte-containing and pure platelet-rich plasma (PRP) on tendon stem/progenitor cells – implications of PRP application for the clinical treatment of tendon injuries. Stem Cell Res Ther. Published online September 15, 2015. doi:10.1186/s13287-015-0172-4

PRP for Jumpers Knee: A Comprehensive Guide

PRP for Jumpers Knee: A Comprehensive Guide