PRP Priapus P-Shot®

P-Shot® for Men Overview – does it really work?

Erectile dysfunction, or ED, is very common and increases with age, affecting about 52% of men between the ages of 40-70.​1​ etc. Unfortunately, treatments for erectile dysfunction are somewhat limited.​2​ Medications such as Viagra or Cialis are available, but these are expensive, may lose effectiveness over time and have unwanted side effects such as flushing or dizziness. Vacuum pumps or injections are available, but are inconvenient.​3​

Platelet-rich plasma is considered very safe, and used in various medical and surgical fields including sports medicine, orthopedic surgery, maxillofacial and oral surgery, ophthalmology, dermatology, wound care, and plastic surgery.​4​ PRP is known to contain a rich array of cytokines and growth factors which promote tissue regeneration through various mechanisms including angiogenesis, nerve repair, and stem cell activation.​4,5​

What does the research say about the P-Shot®?

Although to date there are only a small number of published studies on the use of PRP for the treatment of erectile dysfunction, the data support the procedure as being safe and effective, with a mean improvement in the IIEF-5 score of 4-5 points for most patients in three different studies.​6–8​ Since PRP is derived from a patient’s own body, and is known to stimulate tissue regeneration in other areas, it is seems logical that patients would benefit from such a treatment.

PRP when combined with the use of a vacuum pump has also been shown to cause penile enlargement, with an average gain of 7mm per injection in a study of 1220 patients.​9​ Other studies have indicated that the Priapus shot can also help treat Peyronie’s disease.​6,10​

Dr. Yam is a registered provider of the P-Shot® since 2017, and has performed hundreds of procedures, with overall good results. Our patients have reported improvement in in erectile function as well as increases in penile size and length, and improvement in Peyronie’s disease. Dr. Yam has also given expert talks to international medical organizations, teaching physicians around the world about PRP and the P-Shot® for organizations such as IMCAS Academy and the Forum of Adipose Tissue and Stem Cells, based in Singapore, Malaysia.

At PRP Medical Aesthetics, we specialize in high quality PRP. For more information about the P-Shot®, please feel free to send us a message or book a free consultation online today.

FAQ about the Priapus Shot® / P-Shot®

How does the P-Shot® work?

The Priapus P-Shot® works by using platelet-rich plasma, PRP, to stimulate tissue regeneration in the penis, including blood vessels and nerves, which improve erectile function and sensitivity. The PRP at our clinic is prepared from a sample of the patient’s own blood, which is processed using a double-spin technique to obtain 6-8x concentration of platelets over baseline. Before injection, the PRP is activated with a small amount of calcium solution to obtain platelet rich fibrin matrix (PRFM) which is forms from the activated platelets.

Does the P-Shot® hurt?

Most patients are very comfortable, and experience little to no pain during the procedure, which takes about an hour. At our clinic, we use a prescription high concentration numbing cream as well as local nerve block.

What are the benefits of the Priapus P-Shot®?

Benefits include: improved circulation, stronger, longer lasting erections, improved sensation. The treatment may increase length and girth, especially when combined with the use of a vacuum device. The P-Shot can also help straighten a bent or crooked penis (Peyronie’s diease).

While there is an immediate increase in penis size from the P-Shot, this is mostly from the initial PRP injection, which is gradually absorbed over a few days. The main benefits, including growth of new tissue and improvement in erections usually start at about 3 weeks after the shot, and continue with time. The full effects from a P-Shot may not be seen until 8-12 weeks or longer. After this time, a patient may experience further improvement from a second treatment.

For maximum benefit, use of a penile vacuum pump is recommended. Please note, it is vital that the pump has an accurate pressure gauge, as too much pressure can cause damage to the penile tissue. Recommended pressure is 5-10 mmHg, twice a day, 10 minutes each.

How many P-Shot® treatments do I need?

This depends on a patient’s initial health and erectile function. Each Priapus P-Shot treatment usually leads to incremental improvement in quality and strength of erectile function, (see references above). These benefits are augmented with regular use of a vacuum erection device.

Repeat treatments, if necessary may be considered at about 8-12 week intervals, shorter in some situations, such as using PRP to treat Peyronie’s Disease.

What are pre-treatment instructions for the Priapus P-Shot®?

Be well rested and stay hydrated on the day of treatment. Avoid fatty meals up to 6 hours prior to the procedure. Avoid smoking and alcohol up to 5 days before and after the procedure as they can have a negative affect on platelet function and blood flow. Avoid over the counter medication, (eg. advil, ibuprofen), and supplements (eg garlic, ginseng, ginger, green tea, fish oil, Vitamin E) which may also interfere with platelets . Do not stop any medication which has been prescribed by your doctor.

What are post-treatment instructions for the Priapus P-Shot®?

Following the treatment, there may be some sensitivity after the numbing wears off, but most patients tolerate the mild discomfort. Plain or extra-strength tylenol (acetaminophen) may be used if necessary, although most patients do not need it. We recommend waiting about 24 hours before resuming sexual activity, to allow the PRP to rest in the area. Avoid advil, ibuprofen or other anti-inflammatory medications which may interfere with platelet function. For the same reason, try to avoid or limit alcohol and tobacco products.

How to get a good result from the Priapus P-Shot®?

If you are thinking about the P-Shot, it’s important to find a clinic where high quality PRP is being used, otherwise, the result may not be as good. This involves collecting a minimum of 60mL blood sample and then using a double spin technique for the PRP preparation.

At our clinic, we only use high quality, Health Canada approved PRP kits. The process involves collecting a blood sample of about 60-100mL and then using a double spin preparation technique in order to achieve a concentration of 600-800% platelets over baseline. This level of concentration seems to be the most effective for treating soft tissue when looking at the published scientific studies (see PubMed).
Single spin systems like Regen, Selphyl, or Eclipse won’t give this level of concentration as they can only concentrate to 1.5-1.7X with one spin. Our system (Emcyte) is much more concentrated, 6-8X.

Also, if thinking about the P-Shot®, we would want to do a good medical history to determine if you are a good candidate for it. Medical conditions such as diabetes can interfere with blood flow. Smoking, certain medications, and abnormal hormone levels can also negatively affect male function. We will review all of these things with our clients before going ahead with any procedure.


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    Ciocanel O, Power K, Eriksen A. Interventions to Treat Erectile Dysfunction and Premature Ejaculation: An Overview of Systematic Reviews. Sexual Medicine. Published online September 2019:251-269. doi:10.1016/j.esxm.2019.06.001
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    Andersson K-E. PDE5 inhibitors – pharmacology and clinical applications 20 years after sildenafil discovery. British Journal of Pharmacology. Published online April 25, 2018:2554-2565. doi:10.1111/bph.14205
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    Matz EL, Pearlman AM, Terlecki RP. Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions. Investig Clin Urol. Published online 2018:61. doi:10.4111/icu.2018.59.1.61
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    Alkhayal S, Lourdes M. PO-01-091 Platelet rich plasma penile rejuvenation as a treatment for erectile dysfunction: An update. The Journal of Sexual Medicine. Published online May 2019:S71. doi:10.1016/j.jsxm.2019.03.228
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